ASGSB 2003 Annual Meeting Abstracts
EFFICIENCY OF SYNAPTIC
TRANSMISSION IN RAT HIPPOCAMPUS IS ELEVATED BY HYPERGRAVITY.
Kumei1, R. Shimokawa1, K. Ohya, H. 1, J.
Zeredo2 , R. Fujiyama2 , M. Kimoto2,3 and K.
Toda2. 1Graduate School Tokyo Medical and Dental
University, Tokyo 113-8549,
University Graduate School, Nagasaki 852-8588, 3Japan Women’s
Gravity change (2G, 5 min) modulated the nociceptive response of rats, being
mediated through induction of
in the hypothalamus. However, it is unknown that hypothalamus is the primarily
sensitive site of gravity change or the secondarily affected area via neurons
that are projected from higher CNS including hippocampus. In the present
study, we examined rat hippocampus response to gravity change by analyzing the
efficiency of synaptic transmission after a flash exposure to 2G. We found
that hypergravity increased the amplitude of the negative deflection of the
field potential in the CA1 region after stimulating the Schaffer collateral.
Gravity change may modulate the synaptic plasticity in rat hippocampus.
present study was supported by Grant from Ministry of Science, Education,
Culture of Japan, and properly performed under the control of the Guideline
for Animal Experimentation in Tokyo Medical and
and Nagasaki University)
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