ASGSB 2003 Annual Meeting Abstracts


[112]

EFFICIENCY OF SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPUS IS ELEVATED BY HYPERGRAVITY Y. Kumei1, R. Shimokawa1, K. Ohya, H. 1, J. Zeredo2 , R. Fujiyama2 , M. Kimoto2,3 and K. Toda2. 1Graduate School Tokyo Medical and Dental University, Tokyo 113-8549, 2Nagasaki University Graduate School, Nagasaki 852-8588, 3Japan Women’s University, Tokyo 112-8679, Japan

   Gravity change (2G, 5 min) modulated the nociceptive response of rats, being mediated through induction of b-endorphin in the hypothalamus. However, it is unknown that hypothalamus is the primarily sensitive site of gravity change or the secondarily affected area via neurons that are projected from higher CNS including hippocampus. In the present study, we examined rat hippocampus response to gravity change by analyzing the efficiency of synaptic transmission after a flash exposure to 2G. We found that hypergravity increased the amplitude of the negative deflection of the field potential in the CA1 region after stimulating the Schaffer collateral. Gravity change may modulate the synaptic plasticity in rat hippocampus.

(The present study was supported by Grant from Ministry of Science, Education, Culture of Japan, and properly performed under the control of the Guideline for Animal Experimentation in Tokyo Medical and Dental University and Nagasaki University)

 

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