ASGSB 2003 Annual Meeting Abstracts


BIOCOMPATIBILITY TESTING OF THE SPACE STATION BIOLOGICAL RESEARCH PROJECT INCUBATOR.  M. Kirven-Brooks1, Jacob Cohen1, D. Reiss-Bubenheim2  Michele Conrad4, Jeanne Hale3, Aric Katterhagen, Diana Ly3, Gwo-Shing Sun1, June Sunga1, Diane Yu1 and C. Wade2. 1Lockheed Martin Space Operations, 2NASA, Ames Research Center, 3Foothill-DeAnza Internship Program, 4Education Associates Program, Moffett Field, CA.

   The Space Station Biological Research Project (SSBRP) has designed an Incubator to support life sciences research aboard the International Space Station. Three units have been manufactured and are undergoing a series of performance and qualification tests. As part of this phase of the program, the SSBRP intends to examine the materials and components of the Incubator that come into contact with the specimens to ensure that they are biocompatible, i.e. do not cause any adverse biological reaction. The process has included defining specimens that represent a) a class of organisms with unique sensitivities to environmental cues, and b) model organisms that have the highest likelihood of being proposed for space flight experiments. Once established cultures were available, protocols were developed to permit the measurement of growth, reproduction and viability, optimizing the incubation period, to provide sufficient exposure to the Incubator environment, while minimizing the testing and analysis period, to meet a constrained schedule. Baseline tests were conducted in commercial incubators to assure data reproducibility, to compare lab results to published data, and to develop valid success criteria.  A qualification unit, representative of the flight configuration, was provided by the developer, Lockheed Martin Advanced Technology Center, for testing of Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster and Saccharomyces cerevisiae. Data analyzed to date has shown no significant differences in growth, reproduction or viability parameters, suggesting that the SSBRP Incubator is compatible with biospecimens.

(Supported by NASA: NAS2-02090)


Back to Program) Back to Meeting Program